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Science 8 January 1965:
Vol. 147. no. 3654, pp. 158 - 160
DOI: 10.1126/science.147.3654.158
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Articles

Localization of Calcium-Accumulating Structures in Striated Muscle Fibers

LeRoy L. Costantin 1, Clara Franzini-Armstrong 1, and Richard J. Podolsky 1

1 National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

When frog muscle fibers from which the sarcolemma had been dissected away were perfused with a calcium solution and then treated with oxalate, electron-opaque material, probably calcium oxalate, accumulated in the terminal sacs of the sarcoplasmic reticulum. These regions of calcium accumulation were identified with the intracellular calcium sink that controls the relaxation phase of the contraction-relaxation cycle; their proximity to tubules implicated in intracellular stimulus conduction suggests that they might also be regions from which calcium is released to trigger contraction.


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