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Science 18 December 1964:
Vol. 146. no. 3651, pp. 1585 - 1587
DOI: 10.1126/science.146.3651.1585
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Articles

Mitomycin C: Effect on Ribosomes of Escherichia coli

Hiromi Suzuki 1 and Wendell W. Kilgore 1

1 Agricultural Toxicology and Residue Research Laboratory, University of California, Davis

Sucrose-gradient analyses of cell-free extracts of Escherichia coli B show that the sedimentation patterns are markedly affected by exposure of the cells to mitomycin C; 50S subunits are progressively degraded in the cells after 30 minutes exposure. The 30S subunits, although affected, are less sensitive to the antibiotic than the 50S subunits. Incorporation of uracil-2-C14 into the ribosomal particles by the treated cells is markedly reduced by exposure.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cell Division in Erwinia: Inhibition of Nuclear Body Division in Filaments Grown in Penicillin or Mitomycin C.
E. A. Grula, G. L. Smith, and M. M. Grula (1968)
Science 161, 164
   Abstract »    PDF »
Chloroquine: Mode of Action.
J. Ciak and F. E. Hahn (1966)
Science 151, 347-349
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)