Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 December 1964:
Vol. 146. no. 3651, pp. 1585 - 1587
DOI: 10.1126/science.146.3651.1585
Prev | Table of Contents | Next

Articles

Mitomycin C: Effect on Ribosomes of Escherichia coli

Hiromi Suzuki 1 and Wendell W. Kilgore 1

1 Agricultural Toxicology and Residue Research Laboratory, University of California, Davis

Sucrose-gradient analyses of cell-free extracts of Escherichia coli B show that the sedimentation patterns are markedly affected by exposure of the cells to mitomycin C; 50S subunits are progressively degraded in the cells after 30 minutes exposure. The 30S subunits, although affected, are less sensitive to the antibiotic than the 50S subunits. Incorporation of uracil-2-C14 into the ribosomal particles by the treated cells is markedly reduced by exposure.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cell Division in Erwinia: Inhibition of Nuclear Body Division in Filaments Grown in Penicillin or Mitomycin C.
E. A. Grula, G. L. Smith, and M. M. Grula (1968)
Science 161, 164
   Abstract »    PDF »
Chloroquine: Mode of Action.
J. Ciak and F. E. Hahn (1966)
Science 151, 347-349
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)