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Science 18 December 1964:
Vol. 146. no. 3651, pp. 1580 - 1581
DOI: 10.1126/science.146.3651.1580
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Articles

DDT Antagonism to Dieldrin Storage in Adipose Tissue of Rats

Joseph C. Street 1

1 Department of Animal Husbandry, Utah State University, Logan

Storage of dieldrin in the adipose tissue of female rats was markedly depressed when DDT and dieldrin were fed simultaneously. The amount of dieldrin present in the tissues of rats fed 1 and 10 parts of dieldrin per million was significantly reduced by the addition of 5 ppm DDT to the feed. The addition of 50 ppm DDT to the feed caused a 15-fold reduction in the amount of dieldrin stored in rats fed 1 ppm dieldrin, and a 6-fold reduction in rats fed 10 ppm dieldrin. This antagonistic effect of DDT suggests that the criteria used in predicting the pharmacological effects of combined residues of related insecticides need some revision.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metabolic Interactions Among Environmental Chemicals and Drugs: Environmental chemicals that alter microsomal activity may influence the safety and efficacy of drugs.
A. H. Conney and J. J. Burns (1972)
Science 178, 576-586
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Science. ISSN 0036-8075 (print), 1095-9203 (online)