Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 December 1964:
Vol. 146. no. 3649, pp. 1305 - 1307
DOI: 10.1126/science.146.3649.1305
Prev | Table of Contents | Next

Articles

Transplantation Tolerance Induced in Adult Mice by Protein Overloading of Donors

P. Liacopoulos 1 and J. H. Goode 1

1 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Treatment of donor animals with unrelated antigens can regularly inhibit reactivity of spleen cells against the host, with subsequent induction of specific immune tolerance in the recipient animals if the barrier to histocompatibility is weak. Mice made tolerant in this way accept skin grafts from donor strain animals. In the case of strong differences (in H2 locus) or heterologous (rat-mouse) combinations, the inhibition of the reactivity of the transferred lymphoïd cells against the host is partial, and the skin-graft survival time is significantly prolonged.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)