Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 4 December 1964:
Vol. 146. no. 3649, pp. 1299 - 1300
DOI: 10.1126/science.146.3649.1299
Prev | Table of Contents | Next

Articles

Action of Erythromycin on "Protoplasts" in vivo

Lucien B. Guze 1 and George M. Kalmanson 1

1 Veterans Administration Center and University of California Center for Health Sciences, Los Angeles

Bacteria may persist in "protoplast" form in kidneys after treatment of experimental enterococcal pyelonephritis with penicillin. Erythromycin, while ineffective against the bacterial form of infection, was able to kill "protoplasts" in vivo. This finding is consistent with the hypothesis that intact cell wall interferes with the ingress of erythromycin into the cellular area in which it acts.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunologic "Short Circuits".
G. KRONVALL and R. C. WILLIAMS JR. (1969)
Ann Intern Med 70, 1043-1045
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)