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Science 20 November 1964:
Vol. 146. no. 3647, pp. 1061 - 1062
DOI: 10.1126/science.146.3647.1061
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Articles

Histamine: Differences in Amount Available for Release in Lungs of Guinea Pigs Susceptible and Resistant to Acute Anaphylaxis

Sanford H. Stone 1, P. Liacopoulos 1, Monique Liacopoulos-Briot 1, Thérèse Neveu 1, and B. N. Halpern 1

1 Centre de Recherches Allergiques et Immunologiques, Hôopital Broussais, Paris 14e, France

Susceptibility to acute anaphylaxis in guinea pigs is related to the quantity of liberable histamine available for release in the lung. In highly suscepti-ble Hartley animals this amount can be more than 10 times greater than in the resistant strain 2. Strain 2 and Hartley guinea pigs are equally susceptible to his-tamine toxicity, and their organs fix I131-labeled antibody equally well.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)