beta-Galactosidase: Inactivation of Its Messenger RNA by Ultraviolet Irradiation

doi:10.1126/science.146.3645.791

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Science 6 November 1964:
Vol. 146. no. 3645, pp. 791 - 794
DOI: 10.1126/science.146.3645.791

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$beta$ -Galactosidase: Inactivation of Its Messenger RNA by Ultraviolet Irradiation

P. A. Swenson ¹ and R. B. Setlow ¹

¹ Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

A brief exposure of Escherichia coli cells to an indutcer for $beta$ - galactosidase results in the production of a messenger RNAwhich subsequently expresses itself as $beta$ -galactosidase. Ultravioletirradiation of cells after exposure to the inducer results ina decrease in the amount of $beta$ -galactosidase formed. The messengerRNA formed during the brief exposure to inducer is evidentlyinactivated by the ultraviolet radiation. The decay of messengerRNA activity in irradiated cells has the same kinetics as thatobserved in unirradiated cells.

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