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Science 30 October 1964:
Vol. 146. no. 3644, pp. 661 - 663
DOI: 10.1126/science.146.3644.661
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Articles

Induction of Several Adaptive Enzymes by Actinomycin D

Fred Rosen 1, Prem Nath Raina 1, Richard J. Milholland 1, and Charles A. Nichol 1

1 Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, New York

Although actinomycin D has been used to prevent protein synthesis in experiments of several hours' duration, its effects on the synthesis of adaptive enzymes which are induced over a period of several days have received less attention. Treatment of young rats with doses of actinomycin D, which permitted survival for a period of 5 days, resulted in marked increases in the activities of four hepatic enzymes known to be induced by cortisol: alanine transaminase, tyrosine transaminase, serine dehydrase, and tryptophan pyrrolase. Actinomycin D also induced responses of two of these enzymes in adrenalectomized rats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Turnover of Rat Liver Tyrosine Transaminase: Stabilization after Inhibition of Protein Synthesis.
F. T. Kenney (1967)
Science 156, 525-528
   Abstract »    PDF »
Histone Regulation of Lactic Dehydrogenase in Embryonic Chick Brain Tissue.
B. C. Goodwin and I. W. Sizer (1965)
Science 148, 242-244
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)