Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 October 1964:
Vol. 146. no. 3642, pp. 404 - 405
DOI: 10.1126/science.146.3642.404
Prev | Table of Contents | Next

Articles

Antigen-Binding Activity of 6S Subunits of beta2-Macroglobulin Antibody

Kaoru Onoue 1, Yasuo Yagi 1, Peter Stelos 1, and David Pressman 1

1 Department of Biochemistry Research, Roswell Park Memorial Institute, New York State Department of Health, Buffalo

Direct evidence is provided for the antigen binding activity of the 6S subunits formed by reduction and alkylation of rabbit beta2-macroglobulin antibody. Binding activity of the subunits was clearly demonstrated by radioimmunoelectrophoresis with a preparation of purified rabbit antibody against the p-azobenzenearsonate group, which contained 40 percent of beta2M-antibody. The precipitate arc formed between the subunits and sheep antiserum against rabbit macroglobulin was shown to bind radioactive antigen specifically.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hemagglutinating 7S Subunits of 19S Cold Agglutinins.
A. G. Cooper (1967)
Science 157, 933-935
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)