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Science 16 October 1964:
Vol. 146. no. 3642, pp. 401 - 403
DOI: 10.1126/science.146.3642.401
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Articles

Valence and Affinity of Equine Nonprecipitating Antibody to a Haptenic Group

N. R. Klinman 1, J. H. Rockey 1, and F. Karush 1

1 Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia

A nonprecipitable antibody to a haptenic group has been purified from equine serum. It is a 7S beta2dgr immunoglobulin with high affinity for the specific hapten and two binding sites per antibody molecule. These results rule out univalence and low affinity as explanations of the nonprecipitability of this antibody.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comparative Studies of Antibody Active Sites.
L. Wofsy and D. C. Parker (1967)
Cold Spring Harb Symp Quant Biol 32, 111-116
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Science. ISSN 0036-8075 (print), 1095-9203 (online)