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Science 16 October 1964:
Vol. 146. no. 3642, pp. 400 - 401
DOI: 10.1126/science.146.3642.400
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Articles

Subclasses of Human ggr2-Globulin Based on Differences in the Heavy Polypeptide Chains

William D. Terry 1 and John L. Fahey 1

1 National Cancer Institute, Bethesda, Maryland 20014

Three subclasses of human ggr2-globulin (IgG) molecules were detected in normal human serum with antiserums prepared in monkeys. These subclasses, designated ggr2a-, ggr2b-, and ggr2c-globulins, have antibody activity. The distinguishing antigenic characteristics of each subclass were associated with the heavy polypeptide chains and the F (fast) fragments resulting from treatment of ggr2-globulins with papain.


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