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Science 9 October 1964:
Vol. 146. no. 3641, pp. 252 - 253
DOI: 10.1126/science.146.3641.252
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Articles

Chromosome Aberrations: Their Role in the Etiology of Murine Leukemia

Marvin A. Rich 1, Ryoichi Tsuchida 1, and Richard Siegler 1

1 Laboratory of Cancer Research, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141

If the association between chromosome aberrations and leukemia is a causal one, the aberrations should be present before the appearance of tumor. In a virus-induced murine leukemia in which the pre- and early leukemic stages were defined, aneuploidy was observed only during the later stages of the disease. This suggests that the chromosome alteration results from, rather than initiates, the neoplastic transformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metabolic Controls in Cultured Mammalian Cells: Cultured cells may provide a direct approach to regulation and function in the whole animal.
H. Eagle (1965)
Science 148, 42-51
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Science. ISSN 0036-8075 (print), 1095-9203 (online)