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Science 18 September 1964:
Vol. 145. no. 3638, pp. 1321 - 1322
DOI: 10.1126/science.145.3638.1321
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Articles

Skin Tumorigenesis by 7,12-Dimethylbenz(a)anthracene: Inhibition by Actinomycin D

Harry V. Gelboin 1 and Michael Klein 1

1 Carcinogenesis Studies Branch, National Cancer Institute, Bethesda, Maryland

Topical application of actinomycin D during a short period of time immediately before and after a single application of 7, 12-dimethyl-benz (a)anthracene markedly inhibits subsequent tumor formation. The results indicate that the initial events of carcinogenesis are dependent on DNA-dependent RNA synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transformation by Rous Sarcoma Virus: A Requirement for DNA Synthesis.
J. P. Bader (1965)
Science 149, 757-758
   Abstract »    PDF »
Uracil Mustard: A Potent Inducer of Lung Tumors in Mice.
C. W. Abell, H. L. Falk, M. B. Shimkin, E. K. Weisburger, J. H. Weisburger, and N. Gubareff (1965)
Science 147, 1443-1445
   Abstract »    PDF »


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