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Science 28 August 1964:
Vol. 145. no. 3635, pp. 928 - 929
DOI: 10.1126/science.145.3635.928
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Articles

Dependence of a Gm(b) Antigen on the Quaternary Structure of Human Gamma Globulin

Stephen H. Polmar 1 and Arthur G. Steinberg 1

1 Department of Biology, Western Reserve University, Cleveland 6, Ohio

The antigens associated with the Gm(b) factor of human 7S ggr-globulin differ in Caucasoids and Negroids. The studies reported here show that an antigen, Gm(bw), associated with the Gm(b) of whites but not with that of Negroes, is present on the S (slow) fragment of 7S ggr-globulin obtained by digestion with papain or pepsin. All other Gm antigens thus far studied have been found on the F (fast) fragment. The antigens Inv(a) and Inv(b) were detected on isolated L-chains, and Gm(a) and Gm(b) were detected on isolated H-chains, but Gm(bw) was detected on neither. Recombining the H- and L-chains restored activity for Gm(bw) comparable to that of intact ggr-globulin


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inv(1) Allotype: Effect of Immunoglobulin G Heavy Chain Subtype on Its Expression.
A. G. Steinberg and I. Rostenberg (1969)
Science 164, 1072-1073
   Abstract »    PDF »
Antigenic Determinants Common to Human Immunoglobulins G and M: Importance of Conformational Antigens.
M. Seligmann, C. Miaesco, and G. Meshaka (1966)
Science 154, 790-791
   Abstract »    PDF »
Genetic Factors and Polypeptide Chain Subclasses of Human Immunoglobulin G Detected in Chimpanzee Serums.
F. P. Alepa and W. D. Terry (1965)
Science 150, 1293-1294
   Abstract »    PDF »
Population, Immunogenetic, and Biochemical Studies on the Gm(b) Factors of Human Gamma Globulin.
A. G. Steinberg (1964)
Cold Spring Harb Symp Quant Biol 29, 449-454
   Abstract »    PDF »


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