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Science 28 August 1964:
Vol. 145. no. 3635, pp. 926 - 928
DOI: 10.1126/science.145.3635.926
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Articles

Vitamin K Induced Prothrombin Formation: Antagonism by Actinomycin D

Robert E. Olson 1

1 Department of Biochemistry and Nutrition, Graduate School of Public Health, University of Pittsburgh, Pittsburgh 13, Pennsylvania

Actinomycin D inhibits vitamin K induced formation of prothrombin in chicks deficient in vitamin K. The administration of actinomycin in doses which inhibit prothrombin formation also inhibits synthesis in the liver of RNA from adenosine triphosphate as detected with adenine-8-C14. The results are consistent with a genetic action of vitamin K in inducing RNA formation for the synthesis of clotting proteins


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nutrition and genetics: an expanding frontier: Robert H Herman Memorial Award in Clinical Nutrition Lecture, 2002.
R. E Olson (2003)
Am. J. Clinical Nutrition 78, 201-208
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