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Science 14 August 1964:
Vol. 145. no. 3633, pp. 719 - 721
DOI: 10.1126/science.145.3633.719
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Articles

Atrophy of Skeletal Muscle in Chick Embryos Treated with Botulinum Toxin

Daniel B. Drachman 1

1 Department of Neurology, Tufts University School of Medicine, Boston, Massachusetts

Botulinum toxin was given in large intravenous doses to 7- and 12- day chick embryos. Atrophy of skeletal muscle resulted without significant atrophy of other organs. The histological appearance of muscle was consistent with denervation. The results suggest that neural acetylcholine release may play a significant role in "trophic transmission" from nerve to muscle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cellular patterning of fast and slow fibres in the intermandibularis muscle of chick embryos.
L. G. Robson (1993)
Development 117, 329-339
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Susceptibility of skeletal muscle to Coxsackie A2 virus infection: effects of botulinum toxin and denervation.
C. Andrew, D. Drachman, A Pestronk, and O Narayan (1984)
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Teratogenic Effects of Anticonvulsants.
G. W. Paulson and R. B. Paulson (1981)
Arch Neurol 38, 140-143
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Effect of Neuromuscular Blockade on Enzymatic Activities of Muscles.
D. B. Drachman and F. C. A. Romanul (1970)
Arch Neurol 23, 85-89
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Absence of Taste-Bud Papillae in Familial Dysautonomia.
A. Smith, A. Farbman, and J. Dancis (1965)
Science 147, 1040-1041
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Science. ISSN 0036-8075 (print), 1095-9203 (online)