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Science 7 August 1964:
Vol. 145. no. 3632, pp. 595 - 597
DOI: 10.1126/science.145.3632.595
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Articles

Human Erythrocyte Lactate Dehydrogenase: Four Genetically Determined Variants

Alfred P. Kraus 1 and Charles L. Neely Jr. 1

1 Division of Hematology and Laboratory Medicine, University of Tennessee College of Medicine, Memphis

Four variants of human erythrocyte lactate dehydrogenase (LDH) are described. One of these is similar to the one previously described by Boyer and is interpreted as a variant of LDH-B. The other three are thought to represent variants of LDH-A. Studies of families indicate that LDH-A and LDH-B are under separate genetic control and are inherited as autosomal co-dominants. Evidence is presented that the LDH-A locus is not closely linked to the loci for the ABH and Duffy blood group systems.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lactate Dehydrogenase Isozymes in Parthenogenetic Teiid Lizards (Cnemidophorus).
W. B. Neaves and P. S. Gerald (1968)
Science 160, 1004-1005
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Lactic Dehydrogenase and Metabolism of Human Leukocytes in vitro.
A. D. Bloom and M. Tsuchioka (1967)
Science 156, 979-981
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Polymorphism of Lactate Dehydrogenase in Gelada Baboons.
F. N. Syner and M. Goodman (1966)
Science 151, 206-208
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Lactate Dehydrogenase Isozyme Patterns of Human Platelets and Bovine Lens Fibers.
E. S. Vesell (1965)
Science 150, 1735-1737
   Abstract »    PDF »
Electrophoretic Variation in Enzymes.
C. R. Shaw (1965)
Science 149, 936-943
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Polymorphism of Human Lactate Dehydrogenase Isozymes.
E. S. Vesell (1965)
Science 148, 1103-1105
   Abstract »    PDF »


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