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Science 7 August 1964:
Vol. 145. no. 3632, pp. 585 - 586
DOI: 10.1126/science.145.3632.585
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Articles

Therapeutic Antiviral Action of 5-Trifluoromethyl-2'-deoxyuridine in Herpes Simplex Keratitis

Herbert E. Kaufman 1 and Charles Heidelberger 2

1 Division of Ophthalmology, University of Florida College of Medicine, Gainsville
2 McArdle Memorial Laboratory for Cancer Research, University of Wisconsin School of Medicine, Madison

5-Trifluoromethyl-2'-deoxyuridine (F3TDR) has potent therapeutic antiviral activity in herpes simplex infection of the rabbit cornea with strains of herpes virus both sensitive and resistant to 5-iodo-2'-deoxyuridine, and in corneal infection with vaccinia. 5-Trifluoromethyl uracil is not therapeutically active in herpetic keratitis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In Vivo Antiviral Efficacy of a Dipeptide Acyclovir Prodrug, Val-Val-Acyclovir, against HSV-1 Epithelial and Stromal Keratitis in the Rabbit Eye Model.
B. S. Anand, J. M. Hill, S. Dey, K. Maruyama, P. S. Bhattacharjee, M. E. Myles, Y. E. Nashed, and A. K. Mitra (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2529-2534
   Abstract »    Full Text »    PDF »
Can We Prevent Recurrences of Herpes Infections without Antiviral Drugs? The Weisenfeld Lecture.
H. E. Kaufman (2002)
Invest. Ophthalmol. Vis. Sci. 43, 1325-1329
   Full Text »    PDF »
Trifluridine, Cidofovir, and Penciclovir in the Treatment of Experimental Herpetic Keratitis.
H. E. Kaufman, E. D. Varnell, and H. W. Thompson (1998)
Arch Ophthalmol 116, 777-780
   Abstract »    Full Text »    PDF »
Protection From Experimental Ocular Herpetic Keratitis by a Heat-Killed Virus Vaccine.
J. F. Metcalf (1980)
Arch Ophthalmol 98, 893-896
   Abstract »    PDF »
Trifluridine in Resistant Human Herpetic Keratitis.
R. A. Hyndiuk, R. E. Charlin, and T. V. P. Alpren (1978)
Arch Ophthalmol 96, 1839-1841
   Abstract »    PDF »
Treatment of Vaccinial Keratitis With Trifluorothymidine.
R. A. Hyndiuk, S. Seideman, and J. M. Leibsohn (1976)
Arch Ophthalmol 94, 1785-1786
   Abstract »    PDF »
Newer Compounds in Therapy of Herpes Simplex Keratitis.
R. A. Hyndiuk and H. E. Kaufman (1967)
Arch Ophthalmol 78, 600-605
   Abstract »    PDF »
Physiological Chemistry of the Eye: A Review of Papers Published During 1964.
S. L. BONTING (1965)
Arch Ophthalmol 74, 561-578
   PDF »
Ocular Pharmacology and Toxicology.
P. P. ELLIS (1965)
Arch Ophthalmol 74, 96-129
   PDF »


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