Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 24 July 1964:
Vol. 145. no. 3630, pp. 395 - 397
DOI: 10.1126/science.145.3630.395
Prev | Table of Contents | Next

Articles

Inhibition of 19S Antibody Synthesis by 7S Antibody

Khurshed Sahiar 1 and Robert S. Schwartz 1

1 Blood Research Laboratory, Pratt Clinic-New England Center Hospital and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts

A brief course of treatment with 6-mercaptopurine prevented conversion of 19S to 7S antibodies during the immune response of rabbits to bovine gamma globulin. Specific reactive homologous 7S antibodies given intravenously to animals with such incompletely developed humoral reactions led to an abrupt fall in 19S antibodies. After a lag period the synthesis of 7S antibodies was apparently normal. These results suggest that the concentration of 7S antibodies controls the synthesis of 19S antibodies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Summary: Waiting for the End.
N. Kaj Jerne (1967)
Cold Spring Harb Symp Quant Biol 32, 591-603
   Abstract »    PDF »
{gamma}-Globulin in the Prophylaxis of Posttransfusion Hepatitis.
P. V. Holland, R. M. Rubinson, A. G. Morrow, and P. J. Schmidt (1966)
JAMA 196, 471-474
   Abstract »    PDF »
Antibodies and Immunoglobulins: II. Normal Development and Changes in Disease.
J. L. Fahey (1965)
JAMA 194, 255-258
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)