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Science 10 July 1964:
Vol. 145. no. 3628, pp. 178 - 180
DOI: 10.1126/science.145.3628.178
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Articles

Hypertensive Vascular Disease Produced by Homologous Renin

Georges M. C. Masson 1, Chujiro Kashii 1, Masato Matsunaga 1, and Irvine H. Page 1

1 Research Division, Cleveland Clinic Foundation, Cleveland, Ohio

Administration of rat renin to uninephrectomized rats reproduced most, if not all, the changes (hypertension, vascular disease, hypertrophy of the zona glomerulosa of the adrenals) found after partial constriction of the renal artery. This is taken as evidence that the renal pressor system plays a major role in the pathogenesis of renal hypertension.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)