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Science 10 July 1964:
Vol. 145. no. 3628, pp. 168 - 170
DOI: 10.1126/science.145.3628.168
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Articles

Gamma Globulin Antigenic Types Defined by Heavy Chain Determinants

Rudy E. Ballieux 1, George M. Bernier 1, Kikuo Tominaga 1, and Frank W. Putnam 1

1 Department of Biochemistry, University of Florida College of Medicine, Gainesville

Two populations of immunologically distinguishable 7S gamma globulins in normal human serum and two corresponding antigenic types of myeloma 7S gamma globulins have been detected with rabbit antiserums to proteins associated with pathological conditions, the differences being related to the H-chains of 7S gamma globulin. No relationship exists with type I and type II antigenic classification, determined by L-chains. Human serums with various hereditary gamma globulin (Gm) specificities contain both types of 7S gamma globulin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Studies of Monoclonal Immunoglobulins (M-Components) in Various Kindreds.
R. C. WILLIAMS JR., J. L. ERICKSON, H. F. POLESKY, and W. R. SWAIM (1967)
Ann Intern Med 67, 309-327
   Abstract »    PDF »
Subclasses of Human Immunoglobulin A Based on Differences in the Alpha Polypeptide Chains.
J.-P. Vaerman and J. F. Heremans (1966)
Science 153, 647-649
   Abstract »    PDF »
Subclasses of Human ggr2-Globulin Based on Differences in the Heavy Polypeptide Chains.
W. D. Terry and J. L. Fahey (1964)
Science 146, 400-401
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)