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Science 10 July 1964:
Vol. 145. no. 3628, pp. 167 - 168
DOI: 10.1126/science.145.3628.167
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Articles

Gamma Globulin: Unmasking of Hidden Antigenic Sites on Light Chains

Ralph L. Nachman 1 and Ralph L. Engle Jr. 1

1 New York Hospital-Cornell Medical Center, New York

Normal light (L) chains cleaved from normal pooled human gamma globulin contain immunologic determinants not overtly present in the native unreduced molecule. These hidden determinants are shared with Bence Jones proteins. Similarly, one of two Bence Jones proteins contained immunologic determinants which were not overtly present on the autologous serum myeloma protein.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)