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Science 10 July 1964:
Vol. 145. no. 3628, pp. 157 - 159
DOI: 10.1126/science.145.3628.157
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Articles

Identification of Acetylcholine in Sympathetic Ganglia by Chemical and Physical Methods

Abram J. D. Friesen 1, John W. Kemp 1, and Dixon M. Woodbury 1

1 Department of Pharmacology, College of Medicine, University of Utah, Salt Lake City

Extracts of sympathetic ganglionic chains contain a substance which behaves like acetylcholine biologically, chromatographically, and electrophoretically. The melting point of the tetrachloroaurate salt of this substance is identical to that of acetylcholine tetrachloroaurate. No other choline esters have been detected in these extracts. Perfusion of sympathetic ganglia with C14-choline indicates that C14-acetylcholine is released.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)