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Science 3 July 1964:
Vol. 145. no. 3627, pp. 61 - 63
DOI: 10.1126/science.145.3627.61
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Articles

Pacemaker Neurons: Effects of Regularly Spaced Synaptic Input

Donald H. Perkel 1, Joseph H. Schulman 2, Theodore H. Bullock 2, George P. Moore 2, and José P. Segundo 2

1 Rand Corporation Santa Monica, California
2 Departments of Zoology, Physiology, and Anatomy, and Brain Research Institute, University of California, Los Angeles

The consequences of inhibitory or excitatory synaptic input between pacemaker neurons were predicted mathematically and through digital-computer simulations, and the predicted behavior was found to occur in abdominal ganglia of Aplysia and in stretch receptors of Procambarus. Discharge patterns under conditions that do not involve interneuronal feedback are characteristic and self-stabilizing. Paradoxically, increased arrival rates of inhibitory input can increase firing rates, and increased excitatory input rates can decrease firing rates.


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