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Science 26 June 1964:
Vol. 144. no. 3626, pp. 1590 - 1591
DOI: 10.1126/science.144.3626.1590
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Articles

Polypeptide Chains of Human Gamma-Globulin: Cellular Localization by Fluorescent Antibody

George M. Bernier 1 and John J. Cebra 1

1 Departments of Biochemistry and Microbiology, University of Florida College of Medicine, Gainesville

Fluorescent antibody to antigenically distinct portions of 7S gammaglobulin was used to study the occurrence of H-chains and L-chains of types I and II within single cells. Individual lymphoid cells contained both H-and L-chains, but individual cells did not contain both antigenic types of L-chains.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Primary Antibody-Fab Fragment Complexes: A Flexible Alternative to Traditional Direct and Indirect Immunolabeling Techniques.
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J. Histochem. Cytochem. 52, 1219-1230
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Duplicate Plating of Immune Cell Products: Analysis of Globulin Class Secretion by Single Cells.
B. Merchant and Z. Brahmi (1970)
Science 167, 69-72
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Quantitative Studies of Antibody Production by Plaque-Forming Cells: The in vitro inhibition and enhancement of plaque formation by antibody directed against allotypic specificities determined at the Ab locus.
C.-T. Chou, B. Cinader, and S. Dubiski (1967)
Cold Spring Harb Symp Quant Biol 32, 317-331
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Relationships Between the Heterogeneity of Immunoglobulins and the Differentiation of Plasma Cells.
B. Pernis (1967)
Cold Spring Harb Symp Quant Biol 32, 333-341
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Science. ISSN 0036-8075 (print), 1095-9203 (online)