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Science 26 June 1964:
Vol. 144. no. 3626, pp. 1585 - 1586
DOI: 10.1126/science.144.3626.1585
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Articles

Diphtheria Antitoxin: Antigen-Combining and Toxin-Neutralizing Properties of Papain Fragments

J. John Cohen 1, Maxwell Richter 1, and Bram Rose 1

1 Division of Immunochemistry and Allergy Research, Royal Victoria Hospital, Montreal, Quebec

Papain-digested rabbit antibodies to diphtheria toxoid were separated into three fragments. Fragments I and II combined with toxoid in vitro and neutralized toxin. The ratios of these activities were not the same for fragments I and II, indicating that antitoxic and accessory antibody may be distributed unequally between two classes of antibody.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)