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Science 19 June 1964:
Vol. 144. no. 3625, pp. 1460 - 1462
DOI: 10.1126/science.144.3625.1460
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Articles

Temperature Dependence of Anesthesia in Goldfish

Arthur Cherkin 1 and J. F. Catchpool 1

1 Gates and Crellin Laboratories of Chemistry, California Institute of Technology, Pasadena

The anesthetizing concentrations in water of diethyl ether, chloroform, halothane (CF3CClBrH), and methaxyflurane (CHCl2CF2OCH3) have been determined for temperature-acclimated goldfish (Carassius auratus) at 5° to 30°C. At 20°C, the concentrations that anesthetize 50 percent of the fish are 2160, 167, 76.4, and 57.0 mg/ liter, respectively; the corresponding partial pressures are 13.0, 3.36, 4.12, and 0.67 mm-Hg. The anesthetizing partial pressures increase with body temperature, with enthalpies of 8.6, 13.2, 12.5, and 12.3 kcal/ mole, respectively.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Selective Brain Hypothermia Suppresses Noxious-Evoked Movement in Canines.
R. Takayama, R. Uda, N. Isono, M. Furuse, T. Ohta, T. Kuroiwa, and H. Mori (2005)
Anesth. Analg. 100, 1458-1462
   Abstract »    Full Text »    PDF »
Anesthesia of Artemia Larvae: Method for Quantitative Study.
A. B. Robinson, K. F. Manly, M. P. Anthony, J. F. Catchpool, and L. Pauling (1965)
Science 149, 1255-1258
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)