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Science 12 June 1964:
Vol. 144. no. 3624, pp. 1344 - 1346
DOI: 10.1126/science.144.3624.1344
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Articles

Antibodies to Bradykinin and Angiotensin: A Use of Carbodiimides in Immunology

Theodore L. Goodfriend 1, Lawrence Levine 1, and Gerald D. Fasman 1

1 Graduate Department of Biochemistry, Brandeis University, Waltham 54, Massachusetts

Antibodies to bradykinin and angiotensin have been produced in rabbits by the use of conjugates containing albumin and the hapten, covalently bound. The use of water-soluble carbodiimide reagents provided an easy and rapid method of synthesis of the antigenic conjugates.


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