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Science 5 June 1964:
Vol. 144. no. 3623, pp. 1229 - 1232
DOI: 10.1126/science.144.3623.1229
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Articles

DNA Contents of Chromosome Ph1 and Chromosome 21 in Human Chronic Granulocytic Leukemia

George T. Rudkin 1, David A. Hungerford 1, and Peter C. Nowell 2

1 Institute for Cancer Research, Fox Chase, Philadelphia 11, Pennsylvania
2 Department of Pathology, School of Medicine, University of Pennsylvania Philadelphia 4

The Philadelphia chromosome, characteristic of chronic granulocytic leukemia, contained 61±1 percent as much DNA as a number 21 (or 22) chromosome from which it is believed to be derived. The remaining 39 percent represents 0.5 percent of a diploid chromosome complement, approximately 2 x 107 nucleotide pairs; the method used was not sensitive enough to detect whether it had been translocated to other chromosomes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Depletion of Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatases 1 and 2 by Bcr-Abl Promotes Chronic Myelogenous Leukemia Cell Proliferation through Continuous Phosphorylation of Akt Isoforms.
I. Hirano, S. Nakamura, D. Yokota, T. Ono, K. Shigeno, S. Fujisawa, K. Shinjo, and K. Ohnishi (2009)
J. Biol. Chem. 284, 22155-22165
   Abstract »    Full Text »    PDF »
6-Phosphogluconate Dehydrogenase: Hemizygous Manifestation in a Patient with Leukemia.
P. J. Fialkow, R. Lisker, J. Detter, E. R. Giblett, and C. Zavala (1969)
Science 163, 194-195
   Abstract »    PDF »
Down's Syndrome and Chronic Myelogenous Leukemia.
M. CAWEIN, E. J. LAPPAT, and J. W. RACKLEY (1965)
Arch Intern Med 116, 505-508
   Abstract »    PDF »
The Philadelphia Chromosome and Some Others.
D. A. HUNGERFORD (1964)
Ann Intern Med 61, 789-793
   Abstract »    PDF »


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