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Science 5 June 1964:
Vol. 144. no. 3623, pp. 1222 - 1223
DOI: 10.1126/science.144.3623.1222
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Articles

Procaine Action: Antagonism by Adenosine Triphosphate and Other Nucleotides

Albert S. Kuperman 1, Michiko Okamoto 1, Annette M. Beyer 1, and William A. Volpert 1

1 Department of Pharmacology, Cornell University Medical College, New York 10021

Appropriate concentrations of adenosine tri-, di-, and monophosphate antagonize the depressant action of procaine on isolated nerve. Some calcium ion is required in the external solution in order for these nucleotides to produce their maximum effects. When applied either to normal or sodium deficient nerves, the nucleotides do not increase action-potential amplitude.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Physiology and Pathophysiology of Purinergic Neurotransmission.
G. Burnstock (2007)
Physiol Rev 87, 659-797
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Science. ISSN 0036-8075 (print), 1095-9203 (online)