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Science 5 June 1964:
Vol. 144. no. 3623, pp. 1221 - 1222
DOI: 10.1126/science.144.3623.1221
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Articles

Eserine and Amphetamine: Interactive Effects on Sleeping Time in Mice

Charles D. Barnes 1 and F. H. Meyers 1

1 Department of Pharmacology, University of California Medical Center, San Francisco 22

The sleeping time of mice given pentobarbital was found to be significantly shortened by the injection of eserine or amphetamine. When both eserine and amphetamine were given with pentobarbital the sleeping time, though much shortened, was significantly longer than with the addition of amphetamine alone. Though possessing an analeptic effect of its own, eserine appears to antagonize the analeptic effect of amphetamine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
REM sleep induction by physostigmine infusion during sleep.
N Sitaram, R. Wyatt, S Dawson, and J. Gillin (1976)
Science 191, 1281-1283
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Science. ISSN 0036-8075 (print), 1095-9203 (online)