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Science 29 May 1964:
Vol. 144. no. 3622, pp. 1141 - 1142
DOI: 10.1126/science.144.3622.1141
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Articles

Gamma-Globulin Affinity for Normal Human Tissue of the Central Nervous System

C. Dominique Allerand 1 and Melvin D. Yahr 1

1 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York

Immunofluorescent staining of the serum and cerebrospinal fluid of patients with and without neurological disease demonstrates an affinity of the gamma-globulin fraction for glial cells and myelin sheaths in normal human nervous tissue. This affinity appears to be specific for the 7S gamma-globulin fraction and is not seen with the other major protein fractions of serum and cerebrospinal fluid or with the fluorescein conjugated antisera alone.


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