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Science 29 May 1964:
Vol. 144. no. 3622, pp. 1122 - 1127
DOI: 10.1126/science.144.3622.1122
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Articles

Homocitrulline and Homoarginine Synthesis from Lysine

Wayne L. Ryan 1 and Ibert C. Wells 1

1 Department of Biochemistry, Creighton University, School of Medicine, Omaha, Nebraska

After the injection of L-lysine and uniformly labeled L-lysine-carbon-14 into the rat, labeled homocitrulline and homoarginine are found in the liver and kidney. The ingestion of lysine by seven normal adults results in an increased urinary excretion of homocitrulline and homoarginine. These data suggest the occurrence of an unreported metabolic pathway for lysine in the rat and man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ornithinemia, Hyperammonemia, and Homocitrullinuria: A Disease Associated With Mental Retardation and Possibly Caused by Defective Mitochondrial Transport.
V. Fell, R. J. Pollitt, G. A. Sampson, and T. Wright (1974)
Arch Pediatr Adolesc Med 127, 752-756
   Abstract »    PDF »
Further Studies on Hyperlysinemia Associated With Retardation.
H. GHADIMI, R. ZISCHKA, and V. I. BINNINGTON (1967)
Arch Pediatr Adolesc Med 113, 146-151
   Abstract »    PDF »


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