Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 May 1964:
Vol. 144. no. 3621, pp. 992 - 993
DOI: 10.1126/science.144.3621.992
Prev | Table of Contents | Next

Articles

Affinity and Phosphorylation Constants for the Inhibition of Esterases by Organophosphates

A. R. Main 1

1 Pesticide Research Laboratory, North Carolina State University, Raleigh

Equations based on the assumption of a reversible first step in the reaction between organophosphate inhibitors and esterases are proposed for the bimolecular rate constant which now includes an affinity constant and a phosphorylation constant. The treatment applies when the inhibition reaction follows first-order kinetics.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reply to Letter to the Editor.
A. Kousba (2007)
Toxicol. Sci. 98, 605-606
   Full Text »    PDF »
Age-Related Brain Cholinesterase Inhibition Kinetics following In Vitro Incubation with Chlorpyrifos-Oxon and Diazinon-Oxon.
A. A. Kousba, T. S. Poet, and C. Timchalk (2007)
Toxicol. Sci. 95, 147-155
   Abstract »    Full Text »    PDF »
Concentration-Dependent Kinetics of Acetylcholinesterase Inhibition by the Organophosphate Paraoxon.
C. A. Rosenfeld and L. G. Sultatos (2006)
Toxicol. Sci. 90, 460-469
   Abstract »    Full Text »    PDF »
Blood Acylpeptide Hydrolase Activity Is a Sensitive Marker for Exposure to Some Organophosphate Toxicants.
G. B. Quistad, R. Klintenberg, and J. E. Casida (2005)
Toxicol. Sci. 86, 291-299
   Abstract »    Full Text »    PDF »
Comparison of Chlorpyrifos-Oxon and Paraoxon Acetylcholinesterase Inhibition Dynamics: Potential Role of a Peripheral Binding Site.
A. A. Kousba, L. G. Sultatos, T. S. Poet, and C. Timchalk (2004)
Toxicol. Sci. 80, 239-248
   Abstract »    Full Text »    PDF »
Interactions of Rat Brain Acetylcholinesterase with the Detergent Triton X-100 and the Organophosphate Paraoxon.
C. Rosenfeld, A. Kousba, and L. G. Sultatos (2001)
Toxicol. Sci. 63, 208-213
   Abstract »    Full Text »    PDF »
A Small-Volume Bioassay for Quantification of the Esterase Inhibiting Potency of Mixtures of Organophosphate and Carbamate Insecticides in Rainwater: Development and Optimization.
T. Hamers, K. R. J. Molin, J. H. Koeman, and A. J. Murk (2000)
Toxicol. Sci. 58, 60-67
   Abstract »    Full Text »    PDF »
Interactions of the Organophosphates Paraoxon and Methyl Paraoxon with Mouse Brain Acetylcholinesterase.
S. A. Kardos and L. G. Sultatos (2000)
Toxicol. Sci. 58, 118-126
   Abstract »    Full Text »    PDF »
Lophotoxin Is a Slow Binding Irreversible Inhibitor of Nicotinic Acetylcholine Receptors.
D. R. Groebe and S. N. Abramson (1995)
J. Biol. Chem. 270, 281-286
   Abstract »    Full Text »    PDF »
Carbamylation and Binding Constants for the Inhibition of Acetylcholinesterase by Physostigmine ( Eserine).
A. R. Main and F. L. Hastings (1966)
Science 154, 400-402
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)