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Science 15 May 1964:
Vol. 144. no. 3620, pp. 886 - 888
DOI: 10.1126/science.144.3620.886
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Articles

Psychological Changes Associated with Induced Hyperammonemia

Myron Eichler 1

1 Psychiatric Institute, University of Maryland, Baltimore

Normal volunteers infused with ammonium acetate for 3 hours developed a characteristic behavior pattern resembling that of prehepatic coma. They demonstrated certain specific defects in motor performance and recognition aswell as significant lowering of critical flicker fusion. These findings arecorrelated with the concentration of ammonia in arterial blood.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Experimental Ammonia Encephalopathy in the Primate.
M. Cole, R. B. Rutherford, and F. O. Smith (1972)
Arch Neurol 26, 130-136
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Science. ISSN 0036-8075 (print), 1095-9203 (online)