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Science 15 May 1964:
Vol. 144. no. 3620, pp. 868 - 870
DOI: 10.1126/science.144.3620.868
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Articles

Serologic Typing of Human Lymphocytes with Immune Serum Obtained after Homografting

Roy L. Walford 1, Robert Gallagher 1, and John R. Sjaarda 1

1 Department of Pathology, University of California School of Medicine, Los Angeles 24

Serums obtained from paired humans following reciprocal fourthset skin homografts, or from a prolonged series of reciprocal intradermalinjections of leukocytes, displayed potent cytotoxic activity againstlymphocytes of certain individuals and no activity against lymphocytes of other persons. Study of one family suggested that lymphocyte reactivity may be transmitted according to simple Mendelian genetics. Itis probable that this reactivity reflects and can be used to identifyspecific histocompatibility antigens in man.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Modification of Renal Allograft Rejection in Man.
C. B. Carpenter and J. P. Merrill (1969)
Arch Intern Med 123, 501-513
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White Blood Cell Antibodies: Occurrence in Patients Undergoing Open Heart Surgery.
B. G. HATTLER JR., W. G. YOUNG JR., D. B. AMOS, P. HUTCHIN, and M. MacQUEEN (1966)
Arch Surg 93, 741-746
   Abstract »    PDF »
Progress in the Determination of Histocompatibility.
J. W. Streilein, R. E. Billingham, and W. K. Silvers (1966)
JAMA 195, 351-355
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Sixteen Cases Of Renal Homotransplantation.
R. GOLDMAN, W. E. GOODWIN, J. J. KAUFMAN, D. C. MARTIN, R. J. GLASSOCK, and D. S. NOUROK (1964)
Arch Intern Med 114, 601-609
   Abstract »    PDF »
Inhibition of Antibody Plaque Formation by Sensitized Lymphoid Cells: Rapid Indicator of Transplantation Immunity.
H. Friedman (1964)
Science 145, 607-609
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)