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Science 15 May 1964:
Vol. 144. no. 3620, pp. 853 - 854
DOI: 10.1126/science.144.3620.853
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Articles

Immunological Tolerance Induced in Animals Previously Sensitized to Simple Chemical Compounds

J. R. Frey 1, H. Geleick 1, and A. De Weck 2

1 Department of Experimental Medicine, F. Hoffmann-La Roche Co., Ltd., Basel, Switzerland
2 Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland

Adult guinea pigs develop a delayed hypersensitivity to intradermally injected neoarsphenamine. If the animals are treated intravenously with high doses of this compound before sensitization, a specific and permanent immunological tolerance develops. Permanent tolerance is also obtained in previously sensitized animals when an intravenous injection of neoarsphenamine isfollowed 6 hours later by an intradermal one. When, however, the interval between the two injections is extended to 7 or 14 days, no tolerance is observed.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)