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Science 10 April 1964:
Vol. 144. no. 3615, pp. 185 - 187
DOI: 10.1126/science.144.3615.185
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Articles

Estrogen Administered Neonatally Affects Adult Sexual Behavior in Male and Female Rats

Seymour Levine 1 and Richard Mullins Jr. 1

1 Department of Psychiatry, Stanford University School of Medicine, Stanford, California

The injection of 100 µg of estradiol benzoate into female rats 96 hours after birth abolished sexual receptivity in adulthood, even with estrogen and progesterone replacement after ovariectomy. The administration of testosterone propionate to these animals in adulthood elicited the full pattern of male sexual behavior. The same dose of estrogen given to male rats 96 hours after birth produced adults which were unable to achieve intromission, although they mounted as frequently as normal animals. Testosterone replacement after castration in adulthood reproduced this abnormal behavior.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Changes in sexual behavior of adult male and female rats neonatally treated with vitamin D3.
S. Mirzahosseini, C. Karabelyos, O. Dobozy, and G. Csaba (1996)
Human and Experimental Toxicology 15, 573-576
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Ejaculatory pattern in female rats without androgen treatment.
D. Emery and B. Sachs (1975)
Science 190, 484-486
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Pineal Gland: Influence on Development of Copulation in Male Rats.
M. J. Baum (1968)
Science 162, 586-587
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Liver Cancer: Neonatal Estrogen Enhances Induction by a Carcinogen.
J. H. Weisburger, R. S. Yamamoto, J. Korzis, and E. K. Weisburger (1966)
Science 154, 673-674
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Hormonal Influences on Brain Organization in Infant Rats.
S. Levine and R. F. Mullins Jr. (1966)
Science 152, 1585-1592
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Feminine Behavior in Neonatally Castrated and Estrogen-Treated Male Rats.
H. H. Feder and R. E. Whalen (1965)
Science 147, 306-307
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