Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 April 1964:
Vol. 144. no. 3614, pp. 52 - 53
DOI: 10.1126/science.144.3614.52
Prev | Table of Contents | Next

Articles

Urea: Apparent Carrier-Mediated Transport by Facilitated Diffusion in Dogfish Erythrocytes

H. Victor Murdaugh 1, Eugene D. Robin 1, and Claude D. Hearn 1

1 Departments of Medicine, University of Alabama Medical School, Birmingham, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, and Mount Desert Island Biological Laboratory, Salisbury Cove, Maine

The exposure of erythrocytes from the elasmobranch, Squalus acanthias, to solutions isosmotic with plasma (IM) but containing urea or hydroxyurea as the sole solute does not produce hemolysis. Exposure of these cells to IM methylurea, thiourea and acetamide does produce hemolysis. Low concentrations of urea, which are associated with hemolysis, protect dogfish red cells against hemolysis by methylurea and thiourea. Dogfish red cells exposed to mediums containing high concentrations of urea, or no urea, reach 95 percent of their equilibrium concentration in less than 5 minutes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular and functional characterization of a urea transporter from the kidney of the Atlantic stingray.
M. G. Janech, W. R. Fitzgibbon, R. Chen, M. W. Nowak, D. H. Miller, R. V. Paul, and D. W. Ploth (2003)
Am J Physiol Renal Physiol 284, F996-F1005
   Abstract »    Full Text »    PDF »
Methylurea and Acetamide: Active Reabsorption by Elasmobranch Renal Tubules.
B. Schmidt-Nielsen and L. Rabinowitz (1964)
Science 146, 1587-1588
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)