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Science 27 March 1964:
Vol. 143. no. 3613, pp. 1457 - 1459
DOI: 10.1126/science.143.3613.1457
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Articles

Excess Lactate: An Index of Reversibility of Shock in Human Patients

George Broder 1 and Max H. Weil 1

1 University of Southern California, School of Medicine, Los Angeles 33

"Excess lactate," an indicator of oxygen debt, has been studied as a metabolic index of severity of the shock state in human patients. The levels of excess lactate correspond to severity of circulatory failure, and an excess of more than 4 millimoles per liter prognosticates a fatal outcome. The validity of this index was confirmed by studies on experimental hemorrhagic shock in dogs. It provides a parameter for measurement of "reversibility" and serves as an objective clinical guide.


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