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Science 27 March 1964:
Vol. 143. no. 3613, pp. 1454 - 1457
DOI: 10.1126/science.143.3613.1454
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Articles

Actinomycin D: Suppression of Recovery in X-Irradiated Mammalian Cells

M. M. Elkind 1, G. F. Whitmore 2, and T. Alescio 1

1 Laboratory of Physiology, National Cancer Institute, Bethesda, Maryland
2 Ontario Cancer Institute, Toronto, Canda

The lethal effect of two x-ray doses can be considerably enhanced if cultured cells are exposed to actinomycin D between doses. Net survival can be modified by temperature as well as actinomycin treatment. These effects are related to repair of sublethal damage and to cell kinetics between doses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Potentially Lethal Radiation Damage: Repair by Mammalian Cells in Culture.
J. A. Belli and M. Shelton (1969)
Science 165, 490-492
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Science. ISSN 0036-8075 (print), 1095-9203 (online)