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Science 27 March 1964:
Vol. 143. no. 3613, pp. 1440 - 1442
DOI: 10.1126/science.143.3613.1440
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Articles

Molecular and Submolecular Localization of Two Isoantigens of Mouse Immunoglobulins

Robert I. Mishell 1 and John L. Fahey 1

1 Laboratory of Biochemistry and Metabolism Service, National Cancer Institute, Bethesda, Maryland

Three related classes of immunoglobulins ( 7S ggr-, beta2A-, and ggr1M- globulin) in normal C3H and C3H and C57BL/6 mouse serums were isolated and examined for the isoantigens Iga-1 and Iga-2. The results indicate that the genetic locus determining the Iga-1 and Iga-2 antigens affects only a portion of the normal mouse immunoglobulin population (that is, 7S ggr-globulin) and only the ggr-specific part ("F" piece) of the 7S ggr-globulin molecule.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Two-Chain Immunoglobulin A Molecules: Abnormal or Normal Intermediates in Synthesis.
R. Lieberman, J. F. Mushinski, and M. Potter (1968)
Science 159, 1355-1357
   Abstract »    PDF »
Mouse Immunoglobulin Allotypes: Detection with Rabbit Antiserums.
J. E. Coe (1967)
Science 155, 562-567
   Abstract »    PDF »
Linkage in Control of Allotypic Specificities on Two Different ggrG-Immunoglobulins.
R. Lieberman, S. Dray, and M. Potter (1965)
Science 148, 640-642
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)