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Science 20 March 1964:
Vol. 143. no. 3612, pp. 1340 - 1341
DOI: 10.1126/science.143.3612.1340
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Articles

Persistence of Bacteria in "Protoplast" Form after Apparent Cure of Pyelonephritis in Rats

Lucien B. Guze 1 and George M. Kalmanson 1

1 Veterans Administration Center and University of California Center for Health Sciences, Los Angeles 25

Appropriate antibiotic treatment of experimental enterococcal pyelonephritis in the rat appears to effect the removal of the infecting organisms from the kidney, as judged by the culturing of kidney homogenates on standard bacteriological media. When the homogenates were cultured on media containing 0.3M sucrose, osmotically stabilized, it was demonstrated that bacteria were present in the "protoplast" form, and that this form persisted in the kidney for at least 13 weeks after therapy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Long-Term Therapy for Chronic Bacteriuria in Men: U.S. Public Health Service Cooperative Study.
R. B. FREEMAN, W. M. SMITH, J. A. RICHARDSON, P. J. HENNELLY, R. H. THURM, C. URNER, J. A. VAILLANCOURT, R. J. GRIEP, and L. BROMER (1975)
Ann Intern Med 83, 133-147
   Abstract »    PDF »
Wall-Defective Bacteria.
M. Hamburger (1968)
Arch Intern Med 122, 175-178
   Abstract »    PDF »
Immunologic Responses in Urinary-Tract Infections: Prognostic and Diagnostic Evaluation.
J. P. Sanford and J. A. Barnett (1965)
JAMA 192, 587-592
   Abstract »    PDF »
Role of Protoplasts in Pathogenesis of Pyelonephritis.
G. M. Kalmanson and L. B. Guze (1964)
JAMA 190, 1107-1109
   Abstract »    PDF »
Action of Erythromycin on "Protoplasts" in vivo.
L. B. Guze and G. M. Kalmanson (1964)
Science 146, 1299-1300
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)