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Science 20 March 1964:
Vol. 143. no. 3612, pp. 1334 - 1335
DOI: 10.1126/science.143.3612.1334
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Articles

Brucella-Agglutinating Antibodies: Relation of Mercaptoethanol Stability to Complement Fixation

R. K. Anderson 1, Robert Jenness 1, Helene P. Brumfield 1, and Patricia Gough 1

1 Department of Veterinary Bacteriology and Public Health, College of Veterinary Medicine, and Department of Biochemistry, Institute of Agriculture, University of Minnesota, St. Paul 1

Brucella-agglutinating antibodies from selected bovine blood serums and milk samples did not fix complement, and after treatment with 2-mercaptoethanol they lost agglutinating power. After infection of calves with Brucella abortus, strain 19, agglutinins for Brucella that were inactivated by mercaptoethanol appeared earlier than those stable to mercaptoethanol. Under the conditions of these experiments, the appearance and development of complement-fixing capacity coincided closely with the mercaptoethanol stability of the agglutinins for Brucella.


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Development and Evaluation of a Rapid Dipstick Assay for Serodiagnosis of Acute Human Brucellosis.
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An Unusual Outbreak of Brucellosis.
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