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Science 20 March 1964:
Vol. 143. no. 3612, pp. 1330 - 1331
DOI: 10.1126/science.143.3612.1330

Articles

Differences in the Amino Acid Composition of a Third Rabbit Antibody

Marian E. Koshland 1, Frieda M. Englberger 1, and Roslyn Shapanka 1

1 Biology Department, Brookhaven National Laboratory, Upton, New York

Antibody directed against a neutral hapten, p-amino-beta-phenyl lactoside, has been purified, and its amino acid composition has been determined. When the results were compared with the previous analyses of two rabbit antibodies, small but significant differences were found. The demonstration of a third unique antibody composition supports the hypothesis that the amino acid differences are related to specificity rather than to the heterogeneity of ggr-globulin.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)