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Science 6 March 1964:
Vol. 143. no. 3610, pp. 1049 - 1051
DOI: 10.1126/science.143.3610.1049
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Articles

Humoral Thymic Factor in Mice: Further Evidence

L. W. Law 1, N. Trainin 1, R. H. Levey 1, and W. F. Barth 1

1 National Cancer Institute, Bethesda 14, Maryland

Mice of the C3H and DBA strains thymectomized at birth showed a consistent and striking suppression of antibody production (hemolysin response) to sheep erythrocytes. When cell-tight Millipore diffusion chambers containing syngeneic thymic tissue were implanted intraperitoneally, the capacity of these neonatally thymectomized mice to respond to this antigen was restored. The pattern of response and the mean titer were similar to the pattern and mean titer observed in neonatally thymectomized mice bearing subcutaneous grafts of syngeneic thymic tissue. These data are consistent with the concept that thymic tissue within the chamber produced a specific diffusible factor that enabled the thymectomized animal to establish immunologic competence.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bursa of Fabricius in Chickens: Possible Humoral Factor.
R. L. St. Pierre and G. A. Ackerman (1965)
Science 147, 1307-1308
   Abstract »    PDF »
Immune Reactivity in Mice Thymectomized Soon after Birth: Normal Response after Pregnancy.
D. Osoba (1965)
Science 147, 298-299
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)