Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 March 1964:
Vol. 143. no. 3610, pp. 1041 - 1043
DOI: 10.1126/science.143.3610.1041
Prev | Table of Contents | Next

Articles

Actinomycin D: Effect on the Immune Response

Carl J. Wust 1, Clara L. Gall 1, and G. David Novelli 1

1 Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

Actinomycin D injected simultaneously with sheep erythrocytes in female rats caused a delay in the immune response but had no effect on the rate or maximum amount of hemagglutinin produced. The delay was roughly proportional to the concentration of the antibiotic administered, and was up to 2 days for 75 µg in a 200-gram female rat (sublethal dose for females). The dose effect in the delay in response is consistent with the time when actinomycin would no longer be available to bind with newly synthesized DNA and when messenger-RNA production could occur. Similar results were obtained with another antigen, the enzyme beta-galactosidase, in male rats during the secondary response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antibody Induction and Tolerance.
O. Smithies (1965)
Science 149, 151-156
   PDF »
Induction of Several Adaptive Enzymes by Actinomycin D.
F. Rosen, P. N. Raina, R. J. Milholland, and C. A. Nichol (1964)
Science 146, 661-663
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)