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Science 21 February 1964:
Vol. 143. no. 3608, pp. 810 - 813
DOI: 10.1126/science.143.3608.810
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Articles

Radiation-Induced Mouse Leukemia: Consistent Occurrence of an Extra and a Marker Chromosome

Niel Wald 1, Arthur C. Upton 2, Vernon K. Jenkins 2, and Wayne H. Borges 3

1 Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
2 Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee
3 School of Medicine, University of Pittsburgh

Granulocytic leukemia, induced in the primary mouse by x-irradiation, was serially transmitted to RF/Up mice. An extra chromosome, as well as a morphologicaly unusual chromosome, was found in the bone marrow cells of all the leukemic mice that had been injected previously either with leukemic spleen cells or with cell-free ultracentrifugates. This suggests that the changes in the chromosomes are caused by a virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chromosome Changes Induced by Infections in Tissues of Rhynchosciara angelae.
C. Pavan and R. Basile (1966)
Science 151, 1556-1558
   Abstract »    PDF »
Chromosome Studies on a Radiographer and Her Family: Report of One Case of Leukemia and Two Cases of Down's Syndrome.
P. E. CONEN, B. ERKMAN, and B. LASKI (1966)
Arch Intern Med 117, 125-132
   Abstract »    PDF »
Hematodepressive Virus Diseases of Thailand.
H. R. BIERMAN and E. R. NELSON (1965)
Ann Intern Med 62, 867-884
   Abstract »    PDF »
The Philadelphia Chromosome and Some Others.
D. A. HUNGERFORD (1964)
Ann Intern Med 61, 789-793
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)