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Science 14 February 1964:
Vol. 143. no. 3607, pp. 682 - 684
DOI: 10.1126/science.143.3607.682
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Articles

Actinomycin D as a Probe for Nucleic Acid Secondary Structure

Robert Haselkorn 1

1 Committee on Biophysics, University of Chicago, Chicago, Illinois

The binding of actinomycin D to DNA results in an increase in the temperature at which thermal dissociation of the DNA occurs. With this enhancement of thermal stability as a criterion for binding, it is shown that complementary RNA and DNA-RNA hybrid do not bind actinomycin D. This result can be interpreted to mean that these polynucleotides have helical conformations which differ from that of DNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Viroids: structure and function.
T. Diener (1979)
Science 205, 859-866
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Concerning the Stereochemistry of Actinomycin Binding to DNA: An Actinomycin-Deoxyguanosine Crystalline Complex.
H. M. Sobell, S. C. Jain, T. D. Sakore, G. Ponticello, and C. E. Nordman (1972)
Cold Spring Harb Symp Quant Biol 36, 263-270
   Abstract »    PDF »
Actinomycin Binding to DNA: Inability of a DNA Containing Guanine To Bind Actinomycin D.
R. D. Wells (1969)
Science 165, 75-76
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Molecular Mechanisms of Antibiotic Action.
W. CARTER and K. S. MCCARTY (1966)
Ann Intern Med 64, 1087-1113
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Science. ISSN 0036-8075 (print), 1095-9203 (online)