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Science 7 February 1964:
Vol. 143. no. 3606, pp. 588 - 589
DOI: 10.1126/science.143.3606.588
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Articles

Antibody Activity in Six Classes of Human Immunoglobulins

John L. Fahey 1 and Howard Goodman 2

1 Metabolism Service, National Cancer Institute, Bethesda, Maryland
2 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Antibody activity to thyroglobulin was identified in six classes of immunoglobulins in man, that is, in type I and type II, 6.6S ggr-globulins; in type I and type II, beta2A-globulins; and in type I and type II, ggr1-macroglobulins. These observations indicate that antibody-activity sites are separate from the part of the H chains of immunoglobulin molecules responsible for specific properties of 6.6S ggr-globulin, beta2A-globulin, or ggr1M-globulin, and, also, are separate from the part of L chains responsible for type I or type II characteristics of immunoglobulin molecules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hypogammaglobulinemia With Chronic Bronchitis or Bronchiectasis: Treatment of Five Patients With Long-Term Antibiotic Therapy.
R. H. SUHS, H. F. DOWLING, and G. G. JACKSON (1965)
Arch Intern Med 116, 29-38
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Science. ISSN 0036-8075 (print), 1095-9203 (online)